"Preliminary evaluation of a prospective randomized case series comparing plate and screws versus Ilizarov circular external fixator for distal tibial fractures" / Avaliação preliminar de uma série de casos prospectiva e randomizada comparando placa e parafusos x fixador externo circular de Ilizarov para fraturas do pilão tibial

OBJECTIVE: to compare two surgical approaches for fractures of the tibial pilon: open reduction and internal fixation with plate and screws versus closed reduction and external fixation with the Ilizarov circular external fixator, constituting a study with a level of evidence level 4 and seeking to determine which patients benefit most from each surgical approach. METHODS: The research involved 19 patients with fractures of the tibial pilon, divided into two groups according to their respective medical records and evaluated considering the quality of joint reduction, acute complications in relation to these two methods and associated injuries and comorbidities due to a minimum outpatient follow-up of four months. RESULTS: there was no difference in terms of reduction quality, whereas in terms of acute complications and the need for surgical re-approaches, the group of patients undergoing open reduction and internal fixation with plate and screws showed worse results. CONCLUSION: the choice between the methods must be individualized, considering the specific injuries and comorbidities of each patient.

OBJETIVO: comparar duas abordagens cirúrgicas para fraturas do pilão tibial: redução aberta e fixação interna com placa e parafusos versus redução fechada e fixação externa com o fixador externo circular de Ilizarov, constituindo um estudo prospectivo randomizado e busca determinar quais pacientes se beneficiam mais com cada abordagem cirúrgica. MÉTODOS: A pesquisa envolveu 19 pacientes com fraturas do pilão tibial, divididos em dois grupos de acordo com seus respectivos números de prontuário e foram avaliados considerando a qualidade da redução articular, complicações agudas em relação a esses dois métodos e com lesões associadas e comorbidades por um seguimento ambulatorial mínimo de quatro meses. RESULTADOS: não houve diferença quanto a qualidade de redução, já em relação a complicações agudas e necessidade de reabordagens o grupo de pacientes submetido a redução aberta e fixação interna com placa e parafusos apresentou piores resultados. CONCLUSÃO: a escolha entre os métodos deve ser individualizada, considerando as lesões e comorbidades específicas de cada paciente.

Clinical-epidemiological profile of the canine population in a shelter, Minas Gerais, Brazil, 2019-2020.

The aim of this study was to analyze the demographic, clinical, and hematological aspects of the population in a dog shelter located in the municipality of Lavras, Brazil. All animals were microchipped and evaluated by veterinarians. Whole blood samples were obtained from 329 dogs in the months of July-August 2019 and from 310 dogs in the months of January-February 2020. Most of the dogs were of mixed breed, received anti-rabies and polyvalent vaccines (100%), were dewormed (100%), and were spayed/neutered (98.59%), with a predominance of adult (86.51%), short-hair (67.51%), normal body condition (65.57%), medium-size (62.57%), and female (62.36%). The main clinical alterations detected were enlarged lymph nodes (38.69%), skin lesions (31.50%), overweight (23.32%), obesity (6.07%), elevated temperature (17.05%), and ear secretion (15.72%). Regarding hematological alterations, thrombocytopenia (36.31%), leukopenia (15.92%), anemia with decreased hemoglobin values (10.60%), hematocrit (9.70%), and red blood cells (5.14%) were observed. Most of the shelter dogs were apparently healthy, but specific measures for nutritional, dermatological, otological and disease management should be implemented once the health changes are verified, as they impact the general state of the population and adoptions.

Toxicity and Anti-Inflammatory Effects of Agave sisalana Extract Derived from Agroindustrial Residue.

BACKGROUND: In several countries, the leaf juice of Agave sisalana (also known as sisal) is widely used topically, especially as an antiseptic, and orally for the treatment of different pathologies. However, in Brazil, which is the largest producer of Agave sisalana, its residue, which represents the majority of its weight, has been thrown away. For this reason, the determination of the pharmacological and toxicological potentials of sisal residue and its possible therapeutic use is seen as a way to contribute to the sustainable development and social promotion of the largest producer of sisal in Brazil, the interior of Bahia State, which is among the poorest areas in the country. Given the scarcity of available scientific studies on the pharmacological and toxicological properties of sisal residue juice, this study aimed to promote the acid hydrolysis of this juice to potentiate the anti-inflammatory effect already described in the literature. Furthermore, it aimed to evaluate the toxicological profile of the hydrolyzed extract (EAH) and to determine its acute toxicity, as well as its side effects on the reproductive aspects of rats. METHOD: The anti-inflammatory effect of EAH was evaluated in vitro using the induction of hemolysis by hypotonic solution and in vivo in rats using the carrageenan-induced paw edema test and the xylene-induced ear edema test. The acute toxicity, resulting from a single-dose administration, was investigated for some manifestation of toxic symptoms related to motor control and consciousness in rats. At a concentration of 100 mg/kg, by repeated doses, the reproductive toxicity effects of EAH in rats were assessed. RESULTS: In vitro anti-inflammatory activity was positive using the human red blood cell membrane stabilization method. In both in vivo tests used to assess the anti-inflammatory activity, EAH (at three doses) significantly inhibited edema when compared to the control group. At a dose of 50 mg/kg, EAH exhibited a greater effect than indomethacin, a nonsteroidal anti-inflammatory drug with known activity. In vivo toxicological studies have shown that EAH does not present toxic effects when administered orally in a single dose, up to 1000 mg/kg. Finally, EAH promoted a gonadotoxic effect and increased the embryonic mortality rate after implantation. CONCLUSIONS: It is suggested that the anti-edematogenic effect of the acid hydrolysis extract from sisal juice is due to the high concentration of steroidal sapogenins. Therefore, this extract can be considered a potential new anti-inflammatory or even an important sapogenin source for the development of steroidal glucocorticoids. However, further studies are needed to elucidate the chemical composition of sisal juice. Regarding toxicology studies, EAH did not show cytotoxic and clastogenic potentials, but it presented a powerful reproductive toxic effect in rats.

Supplement feed efficiency of growing beef cattle grazing native Campos grasslands during winter: a collated analysis.

Supplementing growing cattle grazing native subtropical Campos grasslands during winter improves the low, even negative, average daily weight gain (ADG) typical of extensive animal production systems in Uruguay. Nonetheless, to render the practice profitable, it is crucial to control supplement feed efficiency (SFE), that is, the difference in ADG between supplemented and control animals (ADGchng) per unit of supplement dry matter (DM) intake. Little has been studied specifically on how SFE varies in these systems. The objective of this study was to quantify the magnitude and variation in SFE of growing beef cattle grazing stockpiled native Campos grasslands during winter and assess putative associations with herbage, animals, supplements, and climatic variables. We compiled data from supplementation trials carried out in Uruguay between 1993 and 2018, each evaluating between one and six supplementation treatments. The average ADG of unsupplemented and supplemented animals were 0.13 ±â€…0.174 and 0.49 ±â€…0.220 kg/animal/day, respectively. In both cases, ADG decreased linearly as the proportion of green herbage in the grazed grassland was lower, but the ADG of unsupplemented animals was further reduced when winter frosts were numerous. Estimated SFE were moderately high, with an average of 0.21 ±â€…0.076 ADGchng/kg DM, resulting from average ADGchng of 0.38 ±â€…0.180 kg/animal/day in response to an average supplementation rate of 1.84 ±â€…0.68 kg supplement DM intake/animal/day (0.86%  ±â€…0.27% body weight). No association was found between SFE and supplementation rate or type (protein vs. energy-based; P > 0.05), but forage allowance negatively affected it, and herbage mass positively affected it, yet in a smaller magnitude, suggesting that a balance is needed between the two to maximize SFE. Weather conditions during trials affected SFE (P < 0.05), with greater SFE in winters with lower temperatures and more frosts. Daytime grazing time was consistently lower in supplemented animals compared to their unsupplemented counterparts, whereas ruminating time during the day was similar, increasing as the proportion of green herbage decreased. Herbage intake estimated from energy balance suggested the existence of some substitution effect. This agrees with the moderately high SFE and with the total digestible nutrients-to-protein ratio of these subtropical humid grasslands being higher than in semi-arid rangelands and dry-season tropical pastures but lower than in sown pastures.

Anti-Inflammatory Effect and Toxicological Profile of Pulp Residue from the Caryocar Brasiliense, a Sustainable Raw Material.

Caryocar brasiliense Cambess is a plant species typical of the Cerrado, a Brazilian biome. The fruit of this species is popularly known as pequi, and its oil is used in traditional medicine. However, an important factor hindering the use of pequi oil is its low yield when extracted from the pulp of this fruit. Therefore, in this study, with aim of developing a new herbal medicine, we an-alyzed the toxicity and anti-inflammatory activity of an extract of pequi pulp residue (EPPR), fol-lowing the mechanical extraction of the oil from its pulp. For this purpose, EPPR was prepared and encapsulated in chitosan. The nanoparticles were analyzed, and the cytotoxicity of the encapsu-lated EPPR was evaluated in vitro. After confirming the cytotoxicity of the encapsulated EPPR, the following evaluations were performed with non-encapsulated EPPR: in vitro anti-inflammatory activity, quantification of cytokines, and acute toxicity in vivo. Once the anti-inflammatory activity and absence of toxicity of EPPR were verified, a gel formulation of EPPR was developed for topical use and analyzed for its in vivo anti-inflammatory potential, ocular toxicity, and previous stability assessment. EPPR and the gel containing EPPR showed effective anti-inflammatory activity and lack of toxicity. The formulation was stable. Thus, a new herbal medicine with anti-inflammatory activity can be developed from discarded pequi residue.

The future of suitable habitats of an endangered Neotropical grassland bird: A path to extinction?

Global changes increasingly worry researchers and policymakers and may have irreversible impacts on Earth's biodiversity. Similar to other phytophysiognomies, natural grasslands suffer from the effects of land use changes and rising temperatures, threatening animal and plant communities. Birds, being very sensitive to these changes, are widely studied and fundamental to understand the dynamics of ecosystems in relation to climate and land use changes. The Campo Miner Geositta poeciloptera is a grassland bird endemic to the Brazilian Cerrado and threatened with extinction that has been widely studied in recent years. We analyze the decrease in its extent of occurrence (EOO) and the effects of climate and land use change to understand the environmental suitability of the species in current and future scenarios. We used 5 common algorithms to produce ecological niche models. For future predictions, we use two general circulation models for two different greenhouse gas emission scenarios with different climate policies, an optimistic (ssp245) and a pessimistic (ssp585), plus two land use models focusing on increasing farmlands and reducing native grasslands. The current EOO represents ~45% of that presented by the IUCN EOO. The models generated for the present were satisfactory (TSS = 0.77 and ROC = 0.90) and showed high environmental suitability in areas where the species is currently found and low suitability where it is already extinct. All future scenarios have reduced suitable areas for the species, and the models of a greater increase in temperature and increase in farmlands and a greater decrease in grasslands were the worse. Our results reinforce the need to care about biome awareness disparity and the importance of actively preserving grassy-shrub areas. Apparently, the state of Minas Gerais will be the only stronghold of the species in the coming years; however, the lack of protected areas that guarantee its survival needs attention.

Transdisciplinaridade entre psicologia e saúde pública, engajamento acadêmico na modalidade remota em época de pandemia / Transdisciplinarity between psychology and public health, academic engagement in remote modality during the pandemic era / Transdisciplinariedad entre psicología y salud pública, engagement académico en modalidad remota durante la era pandémica

OBJETIVO: Comparar o engajamento acadêmico durante a pandemia de COVID-19 em estudantes de duas universidades. METODOLOGIA: Estudo quantitativo, transversal, correlacional, analítico, utilizando a escala de engajamento acadêmico. A amostra foi composta por 650 alunos de psicologia, selecionados durante o ano de 2021 de forma não aleatória por conveniência, em duas universidades da Baixa Califórnia, México, uma privada e outra pública (319 e 331 alunos respectivamente), a escola privada com experiência anterior em educação à distância, e a segunda, com implantação de educação à distância emergencial durante a pandemia do COVID-19, a coleta de dados foi realizada virtualmente por meio de questionário. RESULTADOS: os alunos da universidade com experiência em educação à distância percebem, em média, um nível de engajamento acadêmico maior do que os universitários sem experiência em educação à distância. VALOR: A transdisciplinaridade de pesquisadores-acadêmicos nas áreas de psicologia e saúde coletiva trouxe evidências sobre a importância dos aspectos psicológicos (engajamento acadêmico) em novos paradigmas de pedagogia educacional (educação à distância), em meio a grandes problemas médico-epidemiológicos (pandemia de COVID-19). CONCLUSÕES: Concluiu-se que o nível de engajamento acadêmico dos alunos está vinculado à experiência anterior em educação à distância.

| OBJECTIVE: To compare academic engagement during the COVID-19 pandemic in students from two universities. METHODOLOGY: Quantitative, cross-sectional, correlational, analytical study, using the academic engagement scale. The sample was 650 undergraduate students in psychology, selected during the year 2021 in a non-random manner for convenience at two universities in Baja California, Mexico, one private and the other public (319 and 331 students respectively), the private school with experience previous in remote education, and the public school migrated to emergency remote education during the COVID-19 pandemic, data collection was carried out virtually through a questionnaire. RESULTS: University students with experience in remote education perceive on average a higher level of academic engagement than university students without experience in remote education. VALUE: The transdisciplinarity of researchers-academics in the areas of psychology and public health, provided evidence on the importance of psychological aspects (academic engagement) in new paradigms of educational pedagogy (remote education), in the midst of major medical-epidemiological problems (COVID 19 pandemic). CONCLUSIONS: It is concluded that the level of academic engagement of the students is linked to previous experience in remote education.

OBJETIVO: Comparar el engagement académico durante la pandemia COVID-19 en estudiantes de dos universidades. METODOLOGÍA: Estudio cuantitativo, transversal, correlacional, analítico, utilizando la escala engagement académico. La muestra fue de 650 estudiantes de licenciatura en psicología, seleccionados durante el año 2021 de manera no aleatoria por conveniencia en dos universidades de Baja California, México, una privada y la otra pública (319 y 331 alumnos respectivamente), la escuela privada con experiencia previa en educación remota, y la escuela pública migró a la educación remota de emergencia durante la pandemia COVID-19, la recolección de datos se realizó de manera virtual mediante un cuestionario. RESULTADOS: Los estudiantes de la universidad con experiencia en educación remota perciben en promedio mayor nivel de engagement académico que la universidad sin experiencia en educación remota. VALOR: La transdisciplinariedad de los investigadores-académicos en las áreas de psicología y salud pública, aportó evidencia sobre la importancia de aspectos psicológicos (engagement académico) en nuevos paradigmas de la pedagogía educativa (educación remota), en medio de grandes problemas médico-epidemiológicos (pandemia por COVID 19). CONCLUSIONES: Se concluye que el nivel de engagement académico de los alumnos se vincula a la experiencia previa en educación remota.

Assessment of Predictors of Infection in Primary Knee and Hip Arthroplasty: A Case-control Study.

Objective This study assesses risk factors for periprosthetic joint infection after elective primary total knee or hip arthroplasty. Methods The study included 706 medical records of patients undergoing elective primary total hip or knee arthroplasty from January to December 2018. We used a multivariate analysis of infection predictors through a logistic regression model. The R software performed all statistical analysis. Results The prevalence of infection in the sample was 2.0% (14 cases). Most patients were women (79.6%), with an afflicted right side (50.6%), and underwent a total knee arthroplasty (61.3%). Significant risk factors ( p < 0.05) for infection included surgical time greater than 120 minutes ( p = 0.009) and a history of diabetes ( p = 0.025). Conclusion The risk of infection after elective primary total knee or hip arthroplasty is higher when the surgical procedure is lengthy (over 120 minutes), or the patient has a history of diabetes mellitus. Level of Evidence IIIB, retrospective, case-control study.

Assessment of Predictors of Infection in Primary Knee and Hip Arthroplasty: A Case-control Study / Avaliação de fatores preditores de infecção na artroplastia primária de joelho e quadril: Um estudo caso-controle

Abstract Objective This study assesses risk factors for periprosthetic joint infection after elective primary total knee or hip arthroplasty. Methods The study included 706 medical records of patients undergoing elective primary total hip or knee arthroplasty from January to December 2018. We used a multivariate analysis of infection predictors through a logistic regression model. The R software performed all statistical analysis. Results The prevalence of infection in the sample was 2.0% (14 cases). Most patients were women (79.6%), with an afflicted right side (50.6%), and underwent a total knee arthroplasty (61.3%). Significant risk factors (p< 0.05) for infection included surgical time greater than 120 minutes (p= 0.009) and a history of diabetes (p= 0.025). Conclusion The risk of infection after elective primary total knee or hip arthroplasty is higher when the surgical procedure is lengthy (over 120 minutes), or the patient has a history of diabetes mellitus. Level of EvidenceIIIB, retrospective, case-control study.

Resumo Objetivo Avaliar os fatores de risco para infecção articular periprotética após procedimento cirúrgico eletivo de artroplastia primária total de joelho ou quadril. Métodos Incluem-se no estudo 706 prontuários de pacientes que foram submetidos a artroplastia total primária eletiva de quadril ou joelho entre os meses de janeiro e dezembro de 2018. Utilizou-se a análise multivariada dos fatores preditores de infecção por meio de um modelo de regressão logística. Toda a análise estatística foi realizada no software R. Resultados A prevalência de infecção de toda a amostra foi de 2,0% (14 casos). A amostra contou com a maioria do gênero feminino (79,6%), com o lado direito afetado (50,6%) e predomínio da artroplastia total de joelho (61,3%). Os fatores de risco significativos (p< 0,05) para a infecção foram: tempo cirúrgico maior do que 120 minutos (p= 0,009) e diagnóstico prévio de diabetes (p= 0,025). Conclusão Artroplastias totais primárias eletivas de joelho ou quadril possuem maior risco de infecção quando ocorre um tempo prolongado do procedimento cirúrgico (acima de 120 minutos) e quando o paciente possui diagnóstico prévio de diabetes mellitus. Nível de EvidênciaIIIB, estudo retrospectivo caso-controle.

Meat insights: Uruguayan consumers´ mental associations and motives underlying consumption changes.

A telephone survey (n = 601) was conducted in Uruguay to explore participants' mental associations with meat and the underlying reasons changes in the quantity and type of meat consumed. Participants mentioned mostly positive associations with meat's culinary and cultural aspects and its nutritional value as source of high-quality protein. Other associations were related to meat production, specific types of meat and cuts, meat consumption and pleasure, while price was perceived negatively. Animal welfare concerns emerged as a relevant association, but minor references were made to the effects of meat production on the environment. Changes in the amount and type of meat consumed (higher pork, chicken and cheaper cuts and beef) in the last year were mainly due to price followed by health reasons. Results emphasize the strong meat culture among Uruguayans and reveal that changes in the amount and type of meat consumed last year relate to external (price) or egoistic (health) rather than altruistic motives (ethical or environmental concerns).

Effect of Finishing Diet and Lairage Time on Steers Welfare in Uruguay.

The objective of this experiment was to evaluate the effect of two different pasture-based finishing strategies and lairage time on steers welfare in Uruguayan conditions. Sixty Hereford (H) and Braford (B) steers were assigned to two different diets for finishing purposes: (D1) native pasture plus corn grain (1% of live weight) (H n = 15, B n = 15) and (D2) high-quality pasture (H n = 15, B n = 15). The average daily gain was registered every 14 days, and temperaments were individually assessed one week before slaughter by three individual tests: crush score, flight time and exit speed, building a multicriterial temperament index (TIndex). Animals were slaughtered the same day in two groups (50% from D1 and 50% from D2 in each group) after traveling for 3.5 h and staying 15 (long lairage) and 3 h (short lairage) in the lairage pens, respectively. The behaviors were observed during lairage, and physiological indicators were used to assess stress at the farm after transport, after lairage and at slaughter. Bruises incidence and final pH were registered at the abattoir as a means of assessing the overall animal welfare. Calmer animals had higher average daily gains with no differences either between diets or between breeds. Calmer animals also had a lower stress response during all preslaughter stages, regardless of the time in lairage. Transport did not imply psychological stress (cortisol) for any slaughter group, but physical stress was evident after transport in both groups through NEFA and CPK increases. Bruise incidences did not differ between lairage groups. The short lairage group did not have enough time to cope with the environment before slaughter, with the consequent deleterious effects on the carcass pH. Animals from the long lairage group had a higher metabolic response shown through NEFA values, but they had enough time to rest and recover overnight, reaching final pH values lower than 5.8, considered the upper limit of the normal range. According to this experiment, with pasture-based animals without fasting on the farm and after 3.5 h of transportation, a resting period of 15 h in lairage should be better than a 3-h one.

Resistance of soil to penetration as a parameter indicator of subsolation in crop areas of sugar cane.

Sugarcane is a very important economic crop that relies heavily on agricultural machinery, which contributes to soil compaction and a consequent decline in productivity. Subsoiling operation reduces the problems caused by compression; however, it is necessary to know its location and intensity. Accordingly, the aim of this work is to present a compression diagnostic method based on soil resistance to penetration as the parameter that indicates need for intervention in the subsoil. Measurements of penetration resistance was carried out in areas of sugarcane, located in the municipalities of Goianésia, Barro Alto and Santa Isabel, in the Brazilian state of Goiás. The Falker penetrometer (PLG 1020) was used, adjusted to a maximum depth of 40 cm and adopted as a critical resistance value of 4.0 MPa. The data were interpolated using kriging and adjusted in AutoCAD 2013 (Autodesk). The methodology proved effective in areas of compacted soil, and the surface layer had less resistance. The reduction in soil preparation was 96.54% and when considering the topographic adjustments, the reduction was 74.07%, showing the viability and importance of the diagnosis to show the proper management.

Effect of Different Finishing Strategies and Steer Temperament on Animal Welfare and Instrumental Meat Tenderness.

The aim of this experiment was to evaluate the effect of different fattening systems from pasture to concentrate and temperament on animal welfare (AW) and meat quality (MQ). Eighty-four Hereford steers were randomly assigned to the following groups: T1, pasture (4% of animal live weight: LW); T2, pasture (3% LW) plus concentrate (0.6% LW); T3, pasture (3% LW) plus concentrate (1.2% LW); T4, an ad libitum concentrate treatment. Temperament was assessed by three individual tests: crush score, flight time, and exit speed, building a multicriterial temperament index (TIndex). The flight zone was also registered for each treatment. AW was assessed through the integration of indicators of productivity, physiology, and behavior, as well as by monitoring the health status within each treatment. Shear force was registered for MQ. Differences in average daily gain were due to the different energetic composition of the diets (T4 > T3 > T2 > T1) and were not attributable to animal welfare problems. Animals from T4 had the higher average daily gain (ADG) but welfare was negatively affected, being evident through physiological indicators, the restriction or deprivation of relevant behaviors, diet-related diseases, and mortality. T1, T2, and T3 did not appear to compromise animal welfare. However, strict preventive measures and monitoring should be taken during the habituation process and when using any new diet that includes concentrate, because of possible dietary diseases. Shear force values were lower in T1. None of the animals in our experiment were excitable or aggressive, but there was a positive response to handling in all treatments. In addition, regardless of diet, calmer animals had higher average daily gain and lower shear force values; thus, temperament appears to have a significant influence on productivity and meat quality.

Seasonal Variation in Mycorrhizal Community of Different Cerrado Phytophysiomies.

Purpose: Understanding the dynamics of mycorrhizal fungi in the Cerrado is fundamental for the adoption of conservation practices and for understanding the resilience of this biome in relation to long periods of drought. Thus, this work aimed to verify the dynamics of the mycorrhizal population in five phytophysiognomies of the Cerrado biome. Methods: The samples were taken from the Chapada dos Veadeiros National Park, a permanent preservation with native Cerrado vegetation without any anthropic influence. The five main phytophysiognomies of the Cerrado biome were chosen: the Campo Limpo, Campo Sujo, Cerrado Strictu Sensu, Cerradão, and Veredas. Rhizospherical soil samples were collected in both the wet and dry seasons. Spore density, mycorrhizal colonization rate, easily extractable glomalin, and associated mycorrhizal fungi genera were identified. Results: The values of spore density, mycorrhizal colonization rate, and glomalin were higher in the samples performed during the dry season compared to the samples performed in the rainy season. The same behavior was observed when comparing the different phytophysionomies. Conclusion: Mycorrhizal activity is higher in dry periods when compared to rainy periods. There is no specificity of genera of arbuscular mycorrhizal fungi within the Cerrado phytophysiognomies.

A dimensão tempo na gestão das experiências de lazer em período de pandemia da covid-19 no Brasil / The time dimension in the management of leisure experiences in the pandemic period of covid-19 in Brazil

Este estudo tem como objetivo analisar a dimensão tempo na gestão das experiências de lazer durante o distanciamento social por conta da pandemia COVID-19. A pesquisa, de natureza quali-quantitativa, do tipo descritiva, utilizou estudo de campo mediante a aplicação de um questionário on-line. A amostra foi composta de 2.278 brasileiros, acima de 18 anos. A análise dos dados foi realizada por meio de estatística descritiva e análise de conteúdo. Os resultados indicaram que a maioria dos respondentes teve tempo para as experiências de lazer, embora a maioria também tenha relatado que esse tempo diminuiu neste período. Entre os conteúdos culturais do lazer, os mais vivenciados de acordo com o tempo foram: os virtuais, os intelectuais e os manuais. Sugerem-se novos estudos que abordem esta temática, associando-os a outras dimensões do lazer.

This study aims to analyze the time dimension in the management of leisure experiences during social distancing due to the COVID-19 pandemic. The research, of a quali-quantitative nature, descriptive type, used a field study approach through the application of an online questionnaire. The sample consisted of 2,278 Brazilians, over 18 years of age. Data analysis was performed through descriptive statistics and content analysis. Results indicated that the majority of respondents had time for leisure experiences, although most of them also reported that this time decreased during this period. Among the cultural contents of leisure, the most prevalent were: virtual, intellectuals and manuals experiences. Further studies are recommended to address this theme, by associating them with other dimensions of leisure.

Temporal Variation in Species Abundance and Richness of Culicoides (Diptera: Ceratopogonidae) in a Tropical Equatorial Area.

The aim of this study was to investigate whether temperature, rainfall, and humidity influence the annual distribution of Culicoides Latreille 1809, species abundance and richness in rural areas on São Luís Island in the state of Maranhão, Brazil. Biting midges were collected in housing for domestic animals in the peridomestic areas of 10 homes. A CDC light trap was installed in each peridomestic area from 6:00 p.m. to 6:00 a.m. once a month for 12 mo. In total, 23,633 individuals belonging to 26 Culicoides species were captured. The most abundant species were Culicoides diabolicus Hoffman, 1925 (27.43%), C. ignacioi Forattini, 1957 (25.9%), C. flavivenulus Costa Lima, 1937 (15.53%), C. insignis Lutz, 1913 (10.66%), C. filariferus Hoffman, 1939 (6.21%), C. boliviensis Spinelli & Wirth, 1984 (6.07%), C. foxi Ortíz, 1950 (2.83%), and C. leopoldoi Ortíz, 1951 (2.54%). Species richness and abundance were greater during the rainy season (24 species; 88% of the individuals) than during the dry season (18 species; 12% of individuals). However, persistent rain on the days the midges were collected or in the preceding 24 h adversely affected abundance. Mean monthly maximum temperature and rainfall on the day of the collection adversely affected Culicoides abundance and richness.

The influence of environmental management and animal shelters in vector control of Culicoides (Diptera, Ceratopogonidae) in northeastern Brazil.

We investigated whether biting midges in peridomestic environments are affected by environmental management practices and the presence of domestic animals. We used CDC light traps to collect midges in 112 residences across 24 locations along tourism routes of Maranhão, Brazil. The collection areas were characterized as follows: i) peridomestic area with domestic animals and without management (dirty); ii) peridomestic with domestic animals and management (clean); iii) peridomestic without animals and with management (clean); iv) peridomestic without animals and without management (dirty). The first two treatments had higher biting midge species richness and abundance, respectively. Generalized linear models indicated a positive correlation between the presence of domestic animals and midge abundance, with an approximate four-fold increase in Culicoides (Diptera: Ceratopogonidae) abundance in peridomestic areas with animals. The same model showed that domestic animals have no influence on richness. Environmental management does not appear to influence species richness or abundance of biting midges.

Serum Antibodies to Melanocytes in Patients With Vitiligo Are Predictors of Disease Progression.

The aim of this study was to investigate whether the amount of serum antibodies to melanocyte antigens could predict clinical activity or disease progression in patients with vitiligo. A solid-phase enzyme immunoassay was developed to semiquantitate serum antibodies to a human melanocyte extract and was used in 127 patients, 93 of whom showed clinical progression of the disease, while the remaining 34 were quiescent. Results showed different values for clinical sensitivity and specificity depending on the cutoff level for decision, but the overall performance of the test was adequate and supported statistical significance to predict clinical activity/progression or quietness of the disease process. The test might prove useful in deciding the indication and aggressiveness of immunosuppressive therapy in patients with vitiligo. Previous findings suggest that melanocyte-specific antibodies might play a pathogenetic role in the depletion of melanocytes, which characterizes this disorder, and that this depletion might be due to apoptosis following antibody internalization.

Aplicação de modelos não-lineares para descrever a evolução de características de crescimento e carcaça em bovinos da raça Hereford / Application of nonlinear models to describe the evolution of growth and carcass traits in Hereford cattle

Este trabalho foi desenvolvido com o objetivo de estudar a evolução das características de crescimento e carcaça em função da idade em bovinos da raça Hereford, utilizando modelos não-lineares. Foram utilizados dados de 240 bovinos machos (castrados) da raça Hereford, pertencentes à fazenda Experimental "La Estanzuela" do INIA, Colonia, Uruguai. As características começaram a ser mensuradas a partir da desmama de animais com aproximadamente seis meses de idade, até o abate (dois anos de idade). As medições de peso foram realizadas a cada 15±3 dias durante todo o período e sem jejum prévio. As mensurações de área de olho de lombo, obtidas por ultrassom, e altura dos animais foram obtidas a cada 90 dias, sendo que as medidas de ultrassom foram tomadas entre a 12ª e 13ª costelas. Os modelos não-lineares utilizados foram os modelos de Brody, Gompertz, Logístico e Von Bertalanffy. Para as características peso, altura e área de olho de lombo, todos os modelos avaliados atingiram a convergência. Para descrever a evolução dos dados de peso e área de olho de lombo em função da idade, o modelo de Von Bertalanffy foi o mais indicado, e os modelos de Brody e Logístico mostraram o pior ajuste, respectivamente. A evolução da altura dos animais desde o desmame até os dois anos de idade pode ser modelada através de qualquer um dos modelos não-lineares considerados neste estudo.

The objective of this research was to study the evolution of growth and carcass traits as a function of age in Hereford cattle using nonlinear models. Records from 240 Hereford steers (castrated), belonging to the experimental station "La Estanzuela" of INIA Uruguay, were utilized. The animals were measured from weaning, approximately at 6 months of age, to slaughter (two years of age). The animals were weighed, without fasting, every 15±3 days throughout the period. The measurements of ribeye loin area (between the 12th and 13th rib) were obtained by ultrasound every 90 days. The height of the animals was obtained every 90 days. The Brody, Gompertz, Logistic and Von Bertalanffy nonlinear models were applied to describe the trajectory of weight, height and ribeye loin area along the age. For height, weight and ribeye loin area, all the models reached the convergence. To describe the evolution of weight and ribeye loin area, the Von Bertalanffy nonlinear model was the most suitable. For weight and ribeye loin area, the Brody and Logistic nonlinear models have shown the worst fit, respectively. The height trajectory from weaning until two years of age can be modeled by any of the nonlinear models considered in this research.